Privacy Enhancing Protocols using Pairing Based Cryptography

This thesis presents privacy enhanced cryptographic constructions, consisting of formal definitions, algorithms and motivating applications. The contributions are a step towards the development of cryptosystems which, from the design phase, incorporate privacy as a primary goal. Privacy offers a form of protection over personal and other sensitive data to individuals, and has been the subject of much study in recent years. Our constructions are based on a special type of algebraic group called bilinear groups. We present existing cryptographic constructions which use bilinear pairings, namely Identity-Based Encryption (IBE). We define a desirable property of digital signatures, blindness, and present new IBE constructions which incorporate this property. Blindness is a desirable feature from a privacy perspective as it allows an individual to obscure elements such as personal details in the data it presents to a third party. In IBE, blinding focuses on obscuring elements of the identity string which an individual presents to the key generation centre. This protects an individual's privacy in a direct manner by allowing her to blind sensitive elements of the identity string and also prevents a key generation centre from subsequently producing decryption keys using her full identity string. Using blinding techniques, the key generation centre does not learn the full identity string. In this thesis, we study selected provably-secure cryptographic constructions. Our contribution is to reconsider the design of such constructions with a view to incorporating privacy. We present the new, privacy-enhanced cryptographic protocols using these constructions as primitives. We refine useful existing security notions and present feasible security definitions and proofs for these constructions

De-repression of myelin-regulating gene expression after status epilepticus in mice lacking the C/EBP homologous protein CHOP.

The C/EBP homologous protein CHOP is normally present at low levels in cells but increases rapidly after insults such as DNA damage or endoplasmatic reticulum stress where it contributes to cellular homeostasis and apoptosis. By forming heterodimers with other transcription factors, CHOP can either act as a dominant-negative regulator of gene expression or to induce the expression of target genes. Recent work demonstrated that seizure-induced hippocampal damage is significantly worse in mice lacking CHOP and these animals go on to develop an aggravated epileptic phenotype. To identify novel CHOP-controlled target genes which potentially influence the epileptic phenotype, we performed a bioinformatics analysis of tissue microarrays from chop-deficient mice after prolonged seizures. GO analysis revealed genes associated with biological membranes were prominent among those in the chop-deficient array dataset and we identified myelin-associated genes to be particularly de-repressed. These data suggest CHOP might act as an inhibitor of myelin-associated processes in the brain and could be targeted to influence axonal regeneration or reorganisation

Azithromycin for sarcoidosis cough: an open label exploratory clinical trial

Background Chronic cough is a distressing symptom for many people with pulmonary sarcoidosis. Continuous treatment with a macrolide antibiotic may improve cough. We aimed to assess the potential efficacy of azithromycin in patients with sarcoidosis and self-reported cough.Methods We did a non-controlled, open label clinical trial of azithromycin 250 mg once daily for 3 months in patients with pulmonary sarcoidosis who reported a chronic cough. The primary outcome was number of coughs in 24 h. Secondary outcomes were cough visual analog scales and quality of life measured using the Leicester Cough Questionnaire and King's Sarcoidosis Questionnaire. Safety outcomes included QTc interval on ECG. Measurements were made at baseline and after one and 3 months of treatment.Results All 21 patients were white, median age 57 years, 9 males/12 females, median 3 years since diagnosis. Five were taking oral corticosteroids and none were taking other immunosuppressants. Twenty patients completed the trial. The median (range) number of coughs in 24 h was 228 (43–1950) at baseline, 122 (20–704) at 1 month, and 81 (16–414) at 3 months (p=0.002, Friedman's test). The median reduction in cough count at 3 months was 49.6%. There were improvements in all patient-reported outcomes. Azithromycin was well tolerated.Conclusion In a non-controlled open-label trial in people with sarcoidosis who reported a chronic cough, 3 months of treatment with azithromycin led to improvements in a range of cough metrics. Azithromycin should be tested as a treatment for sarcoidosis cough in a randomised placebo-controlled trial

Hegemony and assessment: the student experience of being in a male homogenous higher education computing course

This work emanates from a previous study examining the experiences of male final year students in computing degree programmes that focused on their perceptions as students where they had few, if any, female classmates. This empirical work consisted of focus groups, with the findings outlined here drawn from two groups that were homogeneous with respect to gender. It identified that the masculinisation of computing and the resulting hegemonic masculinity has far-reaching impact. An unanticipated theme was how this homogeneity impacted their course assessments. Students participating in this research identified discomfort with their experience of the institutional hegemonic masculinity. Further work to understand how this hegemonic masculinity impacts teachers is also proposed

Simplified Pairing Computation and Security Implications

Recent progress on pairing implementation has made certain pairings extremely simple and fast to compute. Hence, it is natural to examine if there are consequences for the security of pairing-based cryptography

De-repression of myelin-regulating gene expression after status epilepticus in mice lacking the C/EBP homologous protein CHOP

The C/EBP homologous protein CHOP is normally present at low levels in cells but increases rapidly after insults such as DNA damage or endoplasmatic reticulum stress where it contributes to cellular homeostasis and apoptosis. By forming heterodimers with other transcription factors, CHOP can either act as a dominant-negative regulator of gene expression or to induce the expression of target genes. Recent work demonstrated that seizure-induced hippocampal damage is significantly worse in mice lacking CHOP and these animals go on to develop an aggravated epileptic phenotype. To identify novel CHOP-controlled target genes which potentially influence the epileptic phenotype, we performed a bioinformatics analysis of tissue microarrays from chop-deficient mice after prolonged seizures. GO analysis revealed genes associated with biological membranes were prominent among those in the chop-deficient array dataset and we identified myelin-associated genes to be particularly de-repressed. These data suggest CHOP might act as an inhibitor of myelin-associated processes in the brain and could be targeted to influence axonal regeneration or reorganisation.Health Research BoardScience Foundation Irelan

Endogenous auditory frequency-based attention modulates electroencephalogram-based measures of obligatory sensory activity in humans

Auditory selective attention is the ability to enhance the processing of a single sound source, while simultaneously suppressing the processing of other competing sound sources. Recent research has addressed a long-running debate by showing that endogenous attention produces effects on obligatory sensory responses to continuous and competing auditory stimuli. However, until now, this result has only been shown under conditions where the competing stimuli differed in both their frequency characteristics and, importantly, their spatial location. Thus, it is unknown whether endogenous selective attention based only on nonspatial features modulates obligatory sensory processing. Here, we investigate this issue using a diotic paradigm, such that competing auditory stimuli differ in frequency, but had no separation in space. We find a significant effect of attention on electroencephalogram-based measures of obligatory sensory processing at several poststimulus latencies. We discuss these results in terms of previous research on feature-based attention and by comparing our findings with the previous work using stimuli that differed both in terms of spatial and frequency-based characteristics

Linking data from a large clinical trial with the Australian Cerebral Palsy Register

Aim: To link data from a large maternal perinatal trial with the Australian Cerebral Palsy Register (ACPR) to identify children with cerebral palsy (CP). Method: Deidentified data from the Australasian Collaborative Trial of Magnesium Sulphate (ACTOMgSO₄ ) and the ACPR were linked. Children born from 1996 to 2000 at Australian hospitals who survived and had 2-year paediatric assessments were included. Children identified with CP in: (1) both the ACTOMgSO₄ (2y) and the ACPR (5y), (2) the ACTOMgSO₄ only, and (3) the ACPR only were compared. Results: We included 913 children (492 males, 421 females; mean gestational age at birth 27.8wks [standard deviation 2.1wks]; range 23.0-40.0wks). Eighty-four children received a CP diagnosis: 35 by the ACTOMgSO₄ and the ACPR, 29 by the ACTOMgSO₄ only, and 20 by the ACPR only. The ACTOMgSO₄ diagnosed 76.2% (95% confidence interval [CI] 65.9-84.1) and the ACPR identified 65.5% (95% CI 54.7-74.9). Children born in states/territories with long-standing versus more recently established registers were more likely to be included on the ACPR (p<0.05). Interpretation: Linking deidentified perinatal trial data with the ACPR was achieved. Limitations of both strategies for identifying children with CP in this era (late 1990s and early 2000s) probably explain many of the differences observed, and inform future linkage studies and evaluations of CP-preventive interventions.Emily Shepherd, Sarah Mcintyre, Hayley Smithers-Sheedy, Pat Ashwood, Thomas R Sullivan, Anna te Velde, Lex W Doyle, Maria Makrides, Philippa Middleton, Caroline A Crowthe